Axoft

• Soft, safer brain implants for improved treatment of traumatic brain injuries have been developed and promoted via Harvard Office of Technology Development.¹
• The work aligns with Axoft-style neural interfaces and materials and is relevant to neuroprosthetics and safer chronic brain implants.^{1 1}

Weekly enrichment (2026-07-20)

• Axoft is a Harvard spinout neurotech company (founded 2021 in Cambridge, MA by Paul Le Floch, Tianyang Ye and Prof. Jia Liu) building implantable brain-computer interfaces (iBCIs).²³⁴
• Its probes use a proprietary soft material, Fleuron, reported to be roughly 10,000× softer than the polyimide used in existing iBCIs, reducing tissue scarring and lead migration for stable long-term recording.⁵⁶
• Axoft raised an oversubscribed $55M Series A led by C.P. Group Innovation (with Alumni Ventures, the Stanford President’s Venture Fund, Hillhouse Investment and Gaorong Ventures), bringing total funding to more than $60M.³⁶
• The capital will expand global clinical trials, advance U.S. regulatory approval, and build a good-manufacturing-practice (GMP) facility to mass-produce iBCIs.³⁶
• The company received approval for first-in-human studies at the end of 2024 and launched its FINESSE study; it reports first-in-human cases in more than 11 patients worldwide.³⁶
• In March–April, neurosurgeons at The Panama Clinic implanted iBCIs in four brain-tumor-resection patients, recording about 20 minutes of activity across cortical layers and subcortical regions to roughly 1 cm depth.⁵
• The Panama study showed the implants were safe to insert and remove and could distinguish conscious from anesthetized (coma-like) states within minutes—information an fMRI might take hours to gather.²
• Axoft is generating preclinical data in porcine traumatic-brain-injury models with Massachusetts General Hospital and targets an FDA-managed TBI trial in 2027, with Nature publications (December 2023, June 2025) demonstrating scalable single-cell electrophysiology.²³

Footnotes

1. https://news.google.com/rss/articles/CBMiZkFVX3lxTE1WbDJ1aFN5NXNjVWxiQUNxc0ZaYnBid3hoWmhqZW4zc3V2UW9iQmFEN1FQMjVaRjkwNzVrdVVYWE1lYXp2ZjQweE9QSDY3dWswd3BmbmlLRGdzZkd3RVVGRzlBWkxKZw?oc=5 ↩ ↩² ↩³

2. https://news.harvard.edu/gazette/story/2025/08/brain-implants-that-dont-leave-scars/ ↩ ↩² ↩³

3. https://www.businesswire.com/news/home/20260429285106/en/Axoft-Secures-%2455M-Series-A-to-Advance-Clinical-Trials-Globally-for-its-Bio-Inspired-Implantable-Brain-Computer-Interface ↩ ↩² ↩³ ↩⁴ ↩⁵

4. https://axoft.us/about ↩

5. https://www.massdevice.com/axoft-completes-first-human-cases-with-ultrasoft-bci/ ↩ ↩²

6. https://www.massdevice.com/axoft-raises-55m-bci-tech/ ↩ ↩² ↩³ ↩⁴