Neural Noise

Corticale

2 min read

  • Corticale is an Italian neurotech company developing minimally invasive, CMOS-based neural implants for brain-computer interfaces.1
  • SiNAPS is Corticale’s flagship technology: a 1024-electrode array enabling single-cell resolution recordings of action potentials and local field potentials deep within cortical tissue.1
  • The platform uses modular probe design and ultra high-density sensors for clinical and research applications.1 1

Weekly enrichment (2026-07-20)

  • SiNAPS stands for Simultaneous Neural Active Pixel Sensors; each probe carries 1,024 independent active recording electrodes spaced 30 µm apart, integrating a low-noise amplifier directly beneath every electrode site to record action potentials and local field potentials at single-cell resolution.23
  • The company is Corticale SRL, based in Genoa, Italy, and co-founded by Fabio Boi, who is described as Chief Technology Officer / Chief Scientific Officer in company and podcast materials.21
  • A peer-reviewed validation study was published in Advanced Science, titled “Multi-Shank 1024 Channels Active SiNAPS Probe for Large Multi-Regional Topographical Electrophysiological Mapping of Neural Dynamics,” demonstrating the platform’s scale, resolution and accuracy for brain mapping and BCI development.2
  • On-shank time-division multiplexing and per-electrode amplification reduce the number of external interconnects and wiring needed to stream data, letting all electrodes on a probe record simultaneously without the pre-selection bottleneck of conventional multiplexed arrays.3
  • Probes are offered in modular 4-shank or 8-shank configurations, enabling distributed sampling across neocortex, hippocampus, striatum and thalamus in the same implant for both mesoscopic LFP and single-neuron recording.3
  • Corticale positions SiNAPS as minimally invasive with each probe measuring less than roughly 100 × 50 µm in cross-section, and describes a patented low-power ultra-wideband (UWB) wireless link for transmitting the high-density data stream at up to 600 Mbit/s.4
  • The BCI platform includes dedicated on-probe stimulation sites for bidirectional communication, targeting treatment of motor- and speech-related brain diseases.4
  • Boi states the modular goal is to record from tens of thousands of cells simultaneously, claiming an information content 10 to 100 times greater than competing technologies while remaining less invasive; these are company/founder claims rather than independently verified clinical figures.2

Footnotes

  1. https://neuralimplantpodcast.com/fabio-boi-on-corticales-ultra-dense-minimally-invasive-brain-interfaces ↩ ↩2 ↩3 ↩4 ↩5

  2. https://www.businesswire.com/news/home/20250428485361/en/Study-Published-in-Advanced-Science-Demonstrates-Scale-Resolution-and-Accuracy-of-Corticale-SiNAPS-Technology-for-Next-generation-Brain-Computer-Interfaces ↩ ↩2 ↩3 ↩4

  3. https://www.corticale.com/technology ↩ ↩2 ↩3

  4. https://www.corticale.com/bci ↩ ↩2

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