Quantitative census of postsynaptic structures in large-scale EM connectomics

• Large volumetric electron microscopy connectomes enable study of subcellular synaptic targeting specificity and its circuit context at unprecedented scale and resolution.¹
• Neurons show cell-type-dependent subcellular specificity (e.g. excitatory neurons preferring to target spines of other excitatory cells); accurate methods for quantifying millions of postsynaptic structures are needed.¹
• A quantitative census in a large EM volume of mouse visual cortex advances methods for connectomics and neural circuit neuroanatomy.^{1 1}

Footnotes

1. https://www.biorxiv.org/content/10.64898/2026.02.19.706834v1?rss=1 ↩ ↩² ↩³ ↩⁴