Neural Noise- In unilateral Parkinson’s disease mice, FUS targeted at the left external globus pallidus (GPe) significantly inhibited GPe calcium activity for ~3 min after stimulation (1).
- The inhibition was accompanied by behavioral readout in freely moving mice (1).
- FUS was delivered with a wearable device; calcium activity was monitored via fiber photometry (1).
- Disease state influenced FUS effects, supporting the importance of disease-state comparison for clinical translation (1). 1