Spatiotemporally distinctive astrocytic and neuronal responses to repetitive ICMS

• A Journal of Neural Engineering study compares spatiotemporal astrocytic and neuronal responses to repetitive intracortical microstimulation (ICMS).¹
• Astrocytes are treated as active modulators of neuronal synaptic transmission, not just passive support cells.¹
• ICMS is widely used to control neuronal activity, but the accompanying astrocytic responses have remained poorly characterized.¹
• Researchers combined ICMS with dual-color in vivo two-photon calcium imaging in mouse visual cortex to record both cell types together.¹
• The dual-color imaging approach maps how astrocytes and neurons respond differently in space and time under repetitive ICMS.¹
• Findings are positioned as relevant to sensory neuroprosthetic stimulation safety and parameter design.^{1 1}

Footnotes

1. https://iopscience.iop.org/article/10.1088/1741-2552/ae829c ↩ ↩² ↩³ ↩⁴ ↩⁵ ↩⁶ ↩⁷