Neural Noise

Multifunctional neural probe for synchronized monitoring of multiple brain signals

2 min read

  • A multifunctional neural probe enables synchronized monitoring of multiple brain signals, supporting better decoding and closed-loop BCI.1
  • The hardware allows concurrent multi-modal brain signal recording and is peer-reviewed (ScienceDirect); tier-1 for instrumentation and neural interfaces.1 1

Gardner updates

  • A multifunctional neural probe enables synchronized monitoring of multiple brain signals for concurrent multi-modal recording, supporting better decoding and closed-loop BCI. 1

Weekly enrichment (2026-07-20)

  • Multifunctional (multimodal) neural probes integrate electrical recording with additional modalities — optical stimulation/photometry for optogenetics and chemical sensing or microfluidic drug delivery — on a single device so that different brain signals can be monitored synchronously.23
  • A recent single-sided multimodal probe (ACS Chemical Neuroscience, 2025) co-locates chemical-sensing and neural-recording electrodes in close proximity, fabricated by a sequential laser-induced graphene process on flexible polyimide without photolithography or multilayer alignment.2
  • That probe used glucose-oxidase and black-platinum functionalization to achieve concentration-dependent glucose detection plus low-impedance spike recording, and in vivo it tracked glucose dynamics while simultaneously acquiring neural spikes in the mouse hippocampal CA3 region.2
  • Co-localizing sensing and recording sites minimizes spatial/temporal mismatch and diffusion delays, enabling more precise temporal correlation between electrical and neurochemical events than earlier platforms.2
  • A multifunctional multi-shank MEMS probe (Nature Communications, 2019) combined simultaneous recording across regions, optogenetic modulation, and deep-brain drug infusion, and was used to confirm the synaptic circuit between hippocampal CA3 and CA1 in transgenic mice.3
  • Polymer fiber-based POLI probes (Advanced Materials) integrate electrophysiology, chemical sensing, optogenetics, photometry, and fluid delivery in MRI-compatible footprints smaller than silica photometry fibers, and were used to interrogate neural activity, calcium signaling, and dopamine release across the mesolimbic pathway.4
  • Reviews of this device class note fabrication routes spanning MEMS/silicon, CMOS, and polymer fiber-drawing, with the shared goal of simultaneously recording and modulating specific neuron populations at cellular scale for circuit studies and closed-loop applications.5
  • The demonstrations in these primary sources are animal-model or in vitro; specific human clinical performance numbers for such synchronized multimodal probes are not reported in the reviewed sources.5

Footnotes

  1. https://news.google.com/rss/articles/CBMie0FVX3lxTE53cHZzT0dvZWlxaXdqWGJaWnkwdm9lMmg4bnlZdXhzT2xGZTRuQVY5VkJpZUpWczFMX0NUWVpDX2o4UTE3aGowbEUyY0xQOF9KNWNkaG5UdFUtUHF1LTBfVTN0Z1BvN3lCWnFhNloyZWV1ckdVN0VjQWVPOA?oc=5 ↩ ↩2 ↩3 ↩4

  2. https://doi.org/10.1021/acschemneuro.5c00952 ↩ ↩2 ↩3 ↩4

  3. https://www.nature.com/articles/s41467-019-11628-5 ↩ ↩2

  4. https://doi.org/10.1002/adma.202408154 ↩

  5. https://pmc.ncbi.nlm.nih.gov/articles/PMC9810608/ ↩ ↩2

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